Study of the anti-tumor activities and effects on the immune function of Sanghuang mushroom polysaccharide in mice

Objective:To study the anti-tumor activities and effects on the immune function of Sanghuang mushroom polysaccharide in mice.Methods:S180 tumor cells were inoculated into 40 healthy mice and the S180 bearing-mice model were constructed.The mice were separated into distilled water control group,and the high,middle and low-dose polysac- charide groups randomly,and anti-tumor rates,celiac macrophage phagocytic index and phagocytic rate,lymphocyte prolif- eration rate,serum hemolysin level,contents of TNF-αIL-4 in serum were calculated.Results:The high,middle and low- dose groups of Sanghuang polysaccharide showed the anti-tumor functions for S180 tumor mice,and celiac macrophage phagocytic index and phagocytic rate,lymphocyte proliferation rate,serum hemolysin level and contents of TNF-αwere ob- viously improved.There was no significant effect on contents of IL-4.Conclusion:Sanghuang polysaccharide has the func- tions of anti-tumor and immune improvement for S180 bearing-mice.