2009•Medical Journal of National Defending Forces in North ChinaRequires access

The Abnormal Expression of cyclin D_1 in Keloid Fibroblast

Jing-long Cai

Abstract

Objective:To explore the abnormal expression of cyclin D1 in keloid fibroblast,and the roles in mechanism of the keloid production pathogeny.Methods:The expression level of cyclin D1 in Keloid fibroblast(KFs)and normal skin fibroblast were taken from 4 respective cases and detected by cell immunohistochemistry and Western Blot.Results:The protein expression level of cyclin D1 in Keloid fibroblast was higher than that in normal skin fibroblast(P0.05);Western Blot results showed that the expression level of cyclin D1 was higher in the lab group than in the control group(P0.05).Conclusion:The abnormal expression of cyclin D1 in keloid fibroblast can play a role in keloid pathogenesis.

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Key concepts: Keloid, Fibroblast, Cyclin D1, Western blot, Immunohistochemistry, Cyclin, Pathogenesis, Cyclin D