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2009•Chinese Journal of Aesthetic MedicineRequires access

Different PDGFR-α and PDGFR-β expression in keloid fibroblasts

Zhen-hua Xu

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Abstract

Objective To study the different PDGFR-α and PDGFR-β expression in keloid fibroblasts.Methods In fibroblasts derived from keloid tissue and normal skin,the protein expression and mRNA expression of PDGFR-α and PDGFR-β were detected by immunocytochemistry staining,western blot and real-time quantitative PCR respectively.Results Compared with those in normal dermal fibroblasts,The protein and mRNA expression of PDGFR-α(P = 0.00,0.00,0.02)but not PDGFR-β(P=0.07,0.06,0.06)increased significantly in keloid fibroblasts.Conclusions The elevated level of PDGFR-α is involved in keloid formation and may play certain role in its pathogenesis.

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Objective To study the different PDGFR-α and PDGFR-β expression in keloid fibroblasts.Methods In fibroblasts derived from keloid tissue and normal skin,the protein expression and mRNA expression of PDGFR-α and PDGFR-β were detected by immunocytochemistry staining,western blot and real-time quantitative PCR respectively.Results Compared with those in normal dermal fibroblasts,The protein and mRNA expression of PDGFR-α(P = 0.00,0.00,0.02)but not PDGFR-β(P=0.07,0.06,0.06)increased significantly in keloid fibroblasts.Conclusions The elevated level of PDGFR-α is involved in keloid formation and may play certain role in its pathogenesis.

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Available abstract

Objective To study the different PDGFR-α and PDGFR-β expression in keloid fibroblasts.Methods In fibroblasts derived from keloid tissue and normal skin,the protein expression and mRNA expression of PDGFR-α and PDGFR-β were detected by immunocytochemistry staining,western blot and real-time quantitative PCR respectively.Results Compared with those in normal dermal fibroblasts,The protein and mRNA expression of PDGFR-α(P = 0.00,0.00,0.02)but not PDGFR-β(P=0.07,0.06,0.06)increased significantly in keloid fibroblasts.Conclusions The elevated level of PDGFR-α is involved in keloid formation and may play certain role in its pathogenesis.

Key concepts: Keloid, Platelet-derived growth factor receptor, Messenger RNA, Western blot, Fibroblast, Immunohistochemistry, Pathogenesis, Pathology

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