Effect of Butylphthalide on the Expression of Caspase-3 and SOD in Hippocampus Tissue of Rats with Cerebral Ischemia-reperfusion

OBJECTIVE: To study the effect of butylphthalide (NBP) on the expression of SOD and Caspase-3 in hippocampus tissue of rats with cerebral ischemia-reperfusion. METHODS: Four-vessel occlusion was used to build cerebral ischemia-reperfusion models. Model rats with neurologic impairment scores of 1～3 grade were randomly divided into model group (edible castor oil), positive control group (nimodipine10 mg·kg-1), treatment group (NBP 25 mg·kg-1) with each group of 12 rats. Sham operation group was also set up (edible castor oil). Each group was given relevant drugs once a day. Two weeks later, neurologic impairment scores were recorded and the expression of SOD and Caspase-3 in hippocampus tissue were detected. RESULTS: Compared with model group, the neurologic impairment scores of positive control group and treatment group decreased significantly, the activity of SOD hippocampus tissue increased while the expression of Caspase-3 decreased (P0.05). There was no significant difference between positive control group and treatment group (P0.05). CONCLUSION: NBP can significantly up-regulate the activity of SOD and down-regulate the expression of Caspase-3 to protect tissue from the ischemia injury.