Effect of Huangqin Qingre Chubi Capsule on Serum IL-1β and IL-6 of Adjuvant Arthritis Rats

Objective To study the therapeutic effect of Huangqin Qingre Chubi capsule(HQCC)on adjuvant arthritis(AA)rats and to explore its possible therapeutic mechanism. Methods An AA rat model was established. From the twelfth day, HQCC in the dose of 51.2, 25.6, 12.8 g·kg-1 was administered orally to the model rats. After administration for 12 continuous days, the secondary pedal swelling and the serum interleukin 1β(IL-1β) and interleukin 6(IL-6) levels in HQCC groups were observed. Results Compared with the normal group, the pedal volume and the levels of IL-1β,IL-6 were elevated significantly in the model group(P 0.05,P 0.01). Compared with the model group, the pedal volume and the levels of IL-1β, IL-6 were reduced significantly in the HQCC groups(P 0.05,P 0.01). Particularly,the effect of the highand middle-dose HQCC was much better(P 0.01compared with that in the model group), but the difference was insignificant compared with the tripterygium glycosides tablets group(P 0.05). Conclusion Huangqin Qingre Chubi capsule can relieve the secondary pedal swelling,and its mechanism is probably related to the decrease of serum IL-1β and IL-6 levels.