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2006•Academic Journal of Guangzhou Medical CollegeRequires access

Detection of Bcr/Abl Fusion Gene by Dual Color ES Probe in Chronic Myeloid Leukemia

Mao Ping

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Abstract

Objective:To investigate the use of fluorescence in situ hybridization(FISH) with bcr/abl dual color ES probe in detection of gene subset of chronic myeloid leukemia(CML).Methods: the bcr/abl fusion gene was detected with FISH in bone marrow cells from 12 CML cases.Results: all of 12 CML cases were bcr/abl gene positive by FISH and 2 cases were associated with ASS gene deletion.Conclusion: the use of FISH with bcr/abl dual color ES probe provided accurate molecular diagnosis for CML.

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What this paper is about

Objective:To investigate the use of fluorescence in situ hybridization(FISH) with bcr/abl dual color ES probe in detection of gene subset of chronic myeloid leukemia(CML).Methods: the bcr/abl fusion gene was detected with FISH in bone marrow cells from 12 CML cases.Results: all of 12 CML cases were bcr/abl gene positive by FISH and 2 cases were associated with ASS gene deletion.Conclusion: the use of FISH with bcr/abl dual color ES probe provided accurate molecular diagnosis for CML.

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Available abstract

Objective:To investigate the use of fluorescence in situ hybridization(FISH) with bcr/abl dual color ES probe in detection of gene subset of chronic myeloid leukemia(CML).Methods: the bcr/abl fusion gene was detected with FISH in bone marrow cells from 12 CML cases.Results: all of 12 CML cases were bcr/abl gene positive by FISH and 2 cases were associated with ASS gene deletion.Conclusion: the use of FISH with bcr/abl dual color ES probe provided accurate molecular diagnosis for CML.

Key concepts: Fusion gene, Myeloid leukemia, ABL, Fluorescence in situ hybridization, breakpoint cluster region, Cancer research, Fish <Actinopterygii>, Gene

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