Clincial effect and safety of letrozole for promoting ovulation in the patients with polycystic ovarian syndrome

Objective To evaluate the promoting ovulation effects of different dosage of letrozole in the treatment of patients with polycystic ovarian syndrome( POS). Methods Eighty- eight patients with POS were randomly divided into control group( n = 42) and treatment group( n = 46). Patients in two groups began to take drug in the third day of menstruation. Patients in the control group were treated with letrozole 2. 5mg· d- 1for 5 days. Patients in the treatment group were treated with letrozole 5. 0 mg·d- 1for 5 days. Ultrasound scanning was performed to monitor the follicle development in 10 thafter menstrual cycle. The ovulation,pregnancy and incidence rate were compared. Results The ovulation rate were 78. 57% and 73. 91% in the control and treatment group respectively,with no significant difference( P 0. 05). The pregnancy rate in the treatment group was significantly higher than in the control group( P 0. 05). The maturity ovary were( 1. 0 ± 0. 4) and( 1. 5 ± 0. 6) in the control and treatment group which indicated the treatment group was much higher( P 0. 05). The adverse drug reactions such as arthralgia and nausea were not significantly differentbetween the two groups( P 0. 05). Conclusion Compared with 2. 5 mg·d- 1letrozole,5. 0 mg·d- 1letrozole can improve the pregnancy rate but with the increasing of adverse drug reactions in patients with POS.