2010•Acta Academiae Medicinae Qingdao UniversitatisRequires access

EFFECTS OF VALSARTAN ON VENTRICULAR REMODELING IN RATS WITH PRESSURE OVERLOAD-INDUCED HEART FAILURE

Zhen Cai

Abstract

Objective To investigate the effects of valsartan on ventricular remodeling in rats with pressure overload-induced heart failure. Methods Rat models of congestive heart failure(CHF) were created by coarctation of aorta,which were randomized to treatment group,model group and sham operative group,with 10 rats in each group.The rats in treatment group were given valsartan(15 mg daily),and all the rats killed after 6 weeks.The left ventricular mass index(LVMI) was calculated and myocardial collagen concentration measured. Results Compared with the sham-operation group,there was significant increase in LVMI and myocardial collagen concentration in model group(F=149.02,5.27;q=23.65,4.27;P0.01).After 6 weeks of treatment,LVMI and myocardial collagen concentration in the therapy group was significantly decreased compared with the model group(q=17.07,3.60;P0.01). Conclusion Valsartan can block and delay the development of CHF by reversing ventricular remodeling.

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Key concepts: Valsartan, Ventricular remodeling, Cardiology, Internal medicine, Medicine, Heart failure, Pressure overload, Ventricular pressure