EXPERIMENTAL STUDY ON TREATMENT OF LIVER FIBROSIS WITH GANXIANKANG DECOCTION

Objective:To study the pharmacological actions of Ganxiankang decoction on experimental liver fibrosis in mice. Method: The animal model of liver fibrosis in mice was induced by carbon tetrachloride.The Ganxiankang decoction was administered by intragastric injection. The levels of alanine aminotransferase (ALT),aspartate aminotransferase(AST),albumin(Alb) in the serum and hydroxyproline(Hyp) in the liver tissue and the pathogenic changes of liver tissue were observed. Result:In model group,the levels of ALT,AST,Hyp were significantly increased,while Alb was significantly decreased and liver fibrosis was obviously observed. After treated with Ganxiankang decoction,the levels of ALT,AST,Hyp were decreased significantly and Alb was markedly increased as compared with those of model group(P0.05 or P0.01) ,and the injury of liver cells and the proliferation degree of collagenous fibers were obviously decreased. Conclusion: Ganxiankang can protect liver function and has preventive effect on liver fibrosis.