Analysis of distribution and antibiotics susceptibility of Acinetobacterisolated from 2688 sputum samples

OBJECTIVE To investigate the drug susceptibility and distribution of Acinetobacter,so as to provide evidence for the rational application of antimicrobial agents.METHODS From Feb.2008 to Apr.2010,totally 127 strains of Acinetobacter were isolated from 2688 sputum specimens,the distribution and drug susceptibility testing results of A.baumannii(ABA) were compared.RESULTS A total of 119 strains of A.baumannii and 8 strains of A.lwoffi were isolated from sputum samples,with the detection rates of 4.4% and 0.3%,respectively.A.baumannii was resistant to 14 common antibiotics,with the average rate of drug resistance reaching 80.9%.ABA was only susceptible to cefoperazone/sulbactam with the susceptibility rate of 65.5%;the resistance rate of A.lwoffi was relatively low with the average resistance rate of 22.1%.ABA isolates were mainly detected from ICU,neurosurgery department,neurology department,and department of respiratory medicine.The multidrug-resistant isolates and pan-drug resistant isolates were significantly more prevalent in these departments than in other departments(P0.05)CONCLUSION A.baumannii is the predominant Acinetobacter isolated from sputum.As the antibiotics are widely used,its drug susceptibility has been dramatically changed.There is a high percentage of multidrug-resistant bacteria and pan-drug resistant bacteria.It is urgent to control the spread of nosocomial infections through further study on resistance mechanism of ABA.