Therapeutic effect of simvastatin on serum lipids and high sensitive C-reactive protein in patients with acute coronary syndrome at the early stage

Objective to observe the effect of simvastatin on serum lipids and high sensitive C-reactive protein(hs-CRP) at the early stage in patients with acute coronary syndrome(ACS).Methods 80 hospitalized patients with ACS were selected and were randomly divided into control group(with placebo for 4 weeks,n=38) and simvastatin group(with simvastatin 20mg per day,n=42).Simvastatin and placebo were used within 48 hours from onset,and there were no other different therapeutic methods between two groups.The concentrations of serum lipids and hs-CRP were detected before and after 4 weeks treatment by ELISA and enzymatic cholesterol assay.Results In simvastatin group,levels of serum total cholesterol(TC),triglycerides(TG),lower density lipid cholesterol(LDL-C) and hs-CRP decreased significantly compared with those before treatment(P0.01),but there was no significant change in control group(P0.05),Conclusion Simvastatin can lower levels of serum lipids and hs-CRP in patients with acute coronary syndrome at the early stage,therefore simvastatin has anti-inflammatory therapeutic effect and may stabilize atherosclerotic plaques.