Value of ~(99m)Tc-DTPA GFR determination in evaluating renal injury in cancer patients after chemotherapy

Objective To explore the value of 99mTc-DTPA glomerular filtration rate(GFR) determination in evaluating the renal injury of cancer patients after chemotherapy.Methods GFR detected by SPECT was determined with 99mTc-DTPA in sixty-three cancer patients underwent chemotherapy and with over-development on SPECT imaging.Serum urea nitrogen(BUN),creatinine(SCr) and B2-microglobulin(B2-MG) were examined.On the basis of GFR values,the patients were divided into three groups of A(15 cases,GFR 80-50 ml/min),B(31 cases,GFR 50-30 ml/min) and C(17 cases,GFR 30 ml/min).Twenty cancer patients without chemotherapy and with normal renal SPECT immage were taken as the controls(group D).The differences of serum BUN,SCr and B2-MG were analyzed among 4 groups.Results GFR was lower in groups of A,B and C than that in group D.Serum B2-MG was higher in group B than that in group D(P0.01).Serum BUN and B2-MG were higher in group C than those in groups of A,B and D(P0.01).Conclusion Compared to serum BUN,SCr and B2-MG examination,99mTc-DTPA GFR determination is more sensitive in the early diagnosis of renal injury in cancer patients after chemotherapy.