Effect of Trimebutine Maleate Combined with Hydrotalcid on Bile Reflux Gastritis

Objective To evaluate the effect of trimebutine maleate combined with hydrotalcid on bile reflux gastritis(BRG).Methods 94 patients with BRG confirmed by gastroscopy and pathology were randomly into groups Ⅰ and Ⅱ,there were 44 patients in group I which were treated with trimebutine maleate 200 mg + hydrotalcid 1 000 mg tid,other 50 patients in group Ⅱ which were treated with itopride hydrochloride 50 mg + hydrotalcid 1 000 mg tid.Symptoms including abdominal pain,abdominal distension,gas,retrostema pain or heartburn,nausea or vomiting were investigated before and 4 weeks after treatment.Gastroscopy was reexamined before and 4 weeks after treatment.Results Every scores of sub-group symptoms,excepting relief of nausea or vomiting,attack frequency and histological integral of gastric mucosa were reduced significantly 4 weeks after treatment when comparing with which before the treatment(P 0.05).Conclusion Trimebutine majeure combined with hydrotalcid can effectively reduce symptoms and gastric mucosa damage of BRG,and perhaps can provides a new choice for the treatment of BRG.