2008•Medical Journal of West ChinaRequires access

Rabeprazole and Trimebutine for treatment of reflux esophagitis

MA Fang-lan

Abstract

Objective To investigate the efficacy and safety of Rabeprazole and Trimebutine in the treatment of reflux esophagitis(RE).Methods 112 cases of RE were randomized to 2 groups:group A group B with 56 cases in each group.Both groups were treated with Trimebutine,100 mg three times daily.Group A were added with Rabeprazole 20mg once daily.Group B were added with Ranitidine 150mg twice daily.Clinical manifestations and gastroscopy results were observed before and 4 weeks,8 weeks after treatment.Results The total effective rate and the healing rate of esophageal mucosal lesion in group A was higher than that of group B at 4 and 8 weeks after treatment(P0.01).Conclusion The efficacy of Rabeprazole and Trimebutine in the treatment of RE is better than that of Ranitidine and Trimebutine.

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Key concepts: Rabeprazole, Medicine, Ranitidine, Reflux esophagitis, Gastroenterology, Internal medicine, Randomized controlled trial, Esophagitis