Time of Daily Continuous Blood Purfication for Pationts with Severe Acute Pancreatitis

Objective To summarize the experience of time of daily continuous blood purification(CBP) for patients with severe acute pancreatitis(SAP) so as to improve the efficacy of treating severe acute pancreatitis.Methods 583 SAP patients with daily CBP of 6~8 h,12~16 h,18~24 h reported in 32 articles were compared with 163 cases with routine medication.Results APACHE Ⅱ scores,hospitalization time,survival rate,morbidities and mortalities in CBP group were significantly better than those of the control group(P0.05).88.67% of the patients showed biochemical improvement and 82.14% showed endotoxic decrease in CBP group seven days after treatment against 45.42% and 40.47% respectively in the control group.There was significantly difference between the two groups (P0.05).But there was no significant difference on APACHE Ⅱscores,survival rates,mortality for daily CBP of 6~8 h,12~16 h and 18~24 h(P0.05).Conclusion Early CBP treatment can significantly improve the APACHE Ⅱ scores,and decrease hospitalization time and mortality.The Effects of Longer time of treatment are similar to the effect of 6~8 h CBP.Moreover,6~8 h CBP can offer a better treatment plan for the other medicines,which forms a theory for time of CBP for SAP patients.