Analysis of continuous blood purification in 11 patients with severe acute pancreatitis

Objective To study the treatment effect of continuous blood purification(CBP) on patients with severe acute pancreatitis(SAP). Methods From November 2004 to Augest 2007,the continuous blood purification was performed in 11 patients(8 male,3 female and mean age 36.7 years) with severe acute pancreatitis . The CBP was performed continuously for 3 to 10 days. The filter was replaced between 24 and 48 hours. The ultrafiltration rate during CBP was 3 000 ～ 6 000 ml/h and blood flow rate was 200 ～ 300 ml/min. Normal heparin was used as anticoagulant. Results Among 11 patients,9 patients relieved and one patient died from severe pulmonary infection with multiple organ failure,the else one patient had given up treatment. There were remarkable improvement in mean arterial blood pressure,heart rate and oxygenation index(P 0.05). The serum amylase[(87.59 ± 31.68) U/L vs pre-treatment(638.65 ± 79.42) U/L],lipase[(190.21 ± 66.50) U/L vs pre-treatment(734.79 ± 86.91) U/L],lactic acid[(1.69 ± 0.82) mmol/L vs pre-treatment(7.11 ± 3.25) mmol/L] and C-reactive protein[(39.33 ± 10.17) mg/L vs pre-treatment(141.21 ± 33.63) mg/L] were also declined(P 0.05). The scores of acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) were declined,too(P 0.05). Conclusion The haemodynamic variables are stabilized during CBP and no obvious side-effects related to CBP is found. The therapy of continuous blood purification can improve the prognosis of the patients with severe acute pancreatitis.