Relationships between Angiogenesis and Cancer Cell Proliferation, Invasion and Metastasis in Invasive Carcinoma of Cervix

Objective To explore the relationships between angiogenesis in early invasive carcinoma of cervix and cancer cell proliferation,invasion and metastasis.Methods The microvascular densities(MVD,labeled by CD 34 ) and expressions of Ki67 antigen in 75 cases of early invasive carcinoma of cervix,18 cases of cervical intraepithelial neoplasis(CIN) and 15 cases of normal cervical epithelium adjacent to tumor were detected by immunohistochemistry SP method,and the relationship between angiogenesis in invasive carcinoma of cervix and proliferation of cancer cells,cancer invasion and metastasis was analyzed statistically.Results The staining reaction of CD 34 was mainly confined to vascular epithelial cells in tumor stroma,whereas that of Ki 67 was mainly to the nucleus in tumor cells.It showed that the MVDs and the rates of positive expression of Ki 67 increased remarkably in the sequence of norma cervical epithelium,CIN and invasive carcinoma of cervix(P0.05).There was relationship between the MVD in invasive carcinoma of cervix and pelvic lymphonode metastasis,intravascular involvement,stroma involvement or Ki 67 expression (P0.05),but no relationship between it and age,FIGO staging,histopathological grading and histopathological involvement,deep stroma involvement or overexpression Ki 67 was significantly higher than that in those without them (P0.05).Conclusion Tumor angiogenesis might play an important role during the canceration,proliferation of cancer cells,cancer invasion and metastasis in cervical carcinoma. High MVD in invasive carcinoma of cervix might lead to active tumor cells proliferation ,cancer invasion and metastasis ,but it was not the only decisive factor.Dection of MVD might be valuable to further understand the biological behavior of cervical carcinoma.