Effect of Antimicrobial Peptides on Growth Performance,Digestive Enzymes and Physicochemical Property of Litters in Piglets Raised in Fermentation Bed

The study investigated the effects of antimicrobial peptides(AMPs)on growth performance,digestive enzyme activities of pancreas and intestinal digesta,disaccharidase of intestinal mucosa in weaned piglets,proteinase and urease activity and the content of ammonium in fermentation-bed litters.108 weaned piglets(35-day-old)with similar body weight were randomly divided into four groups with six replicates in each group and six piglets in each replicate.The weaned piglets in four groups were fed the basal diet(control treatment),basal diet+40mg/kg Bacitracin Zinc+20mg/kg Sulfate Prime Enemy(antibiotic treatment)and basal diet+300 mg/kg Antimicrobial Peptides(AMPs treatment),respectively.The results showed as follows:(1)there was no significant difference in growth performance among the three treatment groups(P0.05).(2)the amylase activitiy of pancreas,duodenum and jejunum digesta in AMPs treatment were significantly higher than that in the control treatment(P0.05),and the trypsin activity of jejunum digesta in AMPs treatment was significantly higher than that in the control treatment(P0.05);the maltase activity of duodenum mucosa in AMPs treatment was significantly higher than that in the control treatment and antibiotic treatment(P0.05),the sucrase and lactase activity of jejunum mucosa in AMPs treatment was significantly higher than that in the control treatment(P0.05),and the sucrase activity of ileum mucosa in AMPs treatment was significantly higher than that in the control treatment(P0.05).(3)there was no significant difference in the activity of proteinase and urease or the content of ammonium in fermentation-bed litters among the three treatments(P0.05).In conclusion,supplementation of 300mg/kg antimicrobial peptides can increase the growth performance to some extent,increase the activity of digestive enzymes in pancreas,intestinal digesta and intestinal mucosa of piglets,and has no adverse effects on the activity of proteinase and urease or content of ammonium in fermentation-bed litters.