2015•Journal of Chinese Practical Diagnosis and TherapyRequires access
Association of serum insulin-like growth factor-1 level with neurologic impairment and clinical prognosis in type 2 diabetes mellitus patients complicated with acute cerebral infarction
Zhao Zhi-ha
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Abstract
Objective To investigate the relationship of insulin-like growth factor-1(IGF-1)with neurologic impairment and clinical prognosis in type 2diabetes mellitus(T2DM)patients complicated with acute cerebral infarction(ACI).Methods Thirty-two T2 DM patients complicated with ACI(ACI+T2DM group)and 33 ACI patients without T2DM(ACI group)were detected IGF-1levels on the 3rd and 14 th days after onset,were assessed neurologic impairment degree by the National Institutes of Health Stroke Scale(NHISS)score,and evaluated the prognosis by modified Rankin scale(MRS)on the 90 th day.The IGF-1levels were detected in 33T2 DM patients without ACI(T2DM group)and 30 healthy volunteers(control group)on the 3rd and 14 th days after admission,and were compared with the other groups.Results The IGF-1levels on the 3rd and 14 th days were the lowest in ACI+T2DM group((88.08±24.22),(114.43±24.54)μg/L),followed by ACI group((99.73±20.25),(125.89±20.35)μg/L),T2 DM group((106.45±19.29),(127.14±19.11)μg/L),and control group((152.50±28.56),(152.56±26.40)μg/L)in turns(P0.01).There were no significant differences between ACI group and T2 DM group(P0.05).The NIHSS scores on the 3rd and 14 th days and MRS score on the 90 th day were significantly higher in ACI+T2DM group(7.44±2.34,4.34±1.86,2.22±1.21)than those in ACI group(5.48±1.87,2.61±1.87,1.64±0.99)(P0.05).NIHSS scores on the 3rd and 14 th days were negatively correlated with IGF-1levels in ACI+T2DM group(r=-0.934,P=0.004;r=-0.821,P=0.000)and ACI group(r=-0.807,P=0.008;r=-0.653,P=0.005).The MRS score on the 90 th day was negatively correlated with IGF-1levels on the 3rd and 14 th days in ACI+T2DM group(r=-0.309,P=0.031;r=-0.306,P=0.029)and ACI group(r=-0.308,P=0.045;r=-0.369,P=0.037).Conclusion The serum IGF-1level in T2 DM patients complicated with ACI can be used to evaluate the severity of disease and predict the prognosis.