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1999•Chinese Journal of Critical Care MedicineRequires access

Antioxide function of dexamethasone and it′s protective effect on the acute liver injury induced by D-GalN/LPS

Tian Cai-qin

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Abstract

Objective To explore the effect of dexamethasone (Dex) on the acute liver injury induced by D-Galactosamine (D-GalN)/lipopolysaccharide(LPS) and the mechanism of its action.Methods Rats were injected intraperitoneally with D-GalN 600 mg/kg plus LPS 0 1 mg/kg and those in the Dex group were pretreated by Dex 4 mg/kg.Results The results showed that serum ALT (375±342 U/L),AST(683±367),TBil(3 21±2 83) in Dex group were significantly lower than that in model group (ALT,2352±698;AST,3548±285;TBil,20 71±5 92 P 0 01).Besides,Dex reduced the elevation of NO in serum and MDA,iron in liver tissues,while SOD and zinc changes were in opposition to MDA.Conclusion The results suggested that Dex has protective effects on the acute liver injury.This function may be correlatted with that Dex can inhibite lipid peroxide and increase the tissues antioxidation. [

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Objective To explore the effect of dexamethasone (Dex) on the acute liver injury induced by D-Galactosamine (D-GalN)/lipopolysaccharide(LPS) and the mechanism of its action.Methods Rats were injected intraperitoneally with D-GalN 600 mg/kg plus LPS 0 1 mg/kg and those in the Dex group were pretreated by Dex 4 mg/kg.Results The results showed that serum ALT (375±342 U/L),AST(683±367),TBil(3 21±2 83) in Dex group were significantly lower than that in model group (ALT,2352±698;AST,3548±285;TBil,20 71±5 92 P 0 01).Besides,Dex reduced the elevation of NO in serum and MDA,iron in liver tissues,while SOD and zinc changes were in opposition to MDA.Conclusion The results suggested that Dex has protective effects on the acute liver injury.This function may be correlatted with that Dex can inhibite lipid peroxide and increase the tissues antioxidation. [

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Available abstract

Objective To explore the effect of dexamethasone (Dex) on the acute liver injury induced by D-Galactosamine (D-GalN)/lipopolysaccharide(LPS) and the mechanism of its action.Methods Rats were injected intraperitoneally with D-GalN 600 mg/kg plus LPS 0 1 mg/kg and those in the Dex group were pretreated by Dex 4 mg/kg.Results The results showed that serum ALT (375±342 U/L),AST(683±367),TBil(3 21±2 83) in Dex group were significantly lower than that in model group (ALT,2352±698;AST,3548±285;TBil,20 71±5 92 P 0 01).Besides,Dex reduced the elevation of NO in serum and MDA,iron in liver tissues,while SOD and zinc changes were in opposition to MDA.Conclusion The results suggested that Dex has protective effects on the acute liver injury.This function may be correlatted with that Dex can inhibite lipid peroxide and increase the tissues antioxidation. [

Key concepts: Medicine, Dexamethasone, Lipopolysaccharide, Internal medicine, Liver function, Liver injury, Lipid peroxide, Endocrinology

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Antioxide function of dexamethasone and it′s protective effect on the acute liver injury induced by D-GalN/LPS — Research Paper | ScholarLens