2003•PubMedRequires access

[Analysis of the poly-genes expression changes in liver by gene expression profile chip in gut ischemia-reperfusion rats].

Yi Lü, Junyou Li, Sen Hu, Hua Jin, Dan Sun, Zhi-yong Sheng

Abstract

OBJECTIVE: To investigate the difference of poly-genes expression between control and gut ischemia-reperfusion rats. METHODS: One thousand one hundred and seventy-six known genes expression in the liver was investigated by means of the cDNA microarray technology to reveal the differential expression genes between control and gut ischemia-reperfusion rats. RESULTS: The analysis data of the cDNA microarray showed that there were 111 genes expression changed over 5 times including 64 genes upregulated and 47 genes downregulated, some of which had not been reported to associated with gut ischemia-reperfusion injury. CONCLUSION: There are many structural and functional genes expression changed in liver of gut ischemia-reperfusion rats, which might be involved in the initiation and the development of SIRS and MODS.

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Key concepts: Gene expression, Gene, Microarray, Complementary DNA, Ischemia, Medicine, Microarray analysis techniques, DNA microarray