2008•Unpublished venueRequires access
The protective effect of allicin on hepatic ischemia reperfusion injury in rats
Shang Wen-guang
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Abstract
Objective To investigate the protective effect and its role of allicin on hepatic ischemia reperfusion injury in rats. Methods Male Sprague-Dawley rats were randomly divided into three groups: pseudo-operation normal control group, hepatic ischemia reperfusion injury model group, allicin group. After hepatic ischemia and reperfusion, to analyze the level of ALT, AST and LDH in the serum and observe the change of MDA and SOD activity of the hepatic tissue. The injury circumstance of the liver tissue in each group were compared by HE staining. Results After hepatic ischemia reperfusion, the MDA level and the content of ALT, AST and LDH increased, and the SOD activity decreased obviously comparing with the normal group(P0.01); Comparing to the hepatic ischemia reperfusion injury model group, the MDA level and the content of ALT,AST and LDH decreased, and the SOD activity increased(P0.05). Conclusions The allicin have a prominent protective effect on hepatic ischemia reperfusion injury in rats.