Analysis of the distribution and antibiotic resistance of Candida isolated from patients with urinary tract infection

Objective To investigate the bacterial distribution and drug resistance of Candida obtained from patients with urinary tract infection,so as to provide references for reasonable clinical use of antibiotics.Methods Urine specimens were cultured in Uricult and susceptibility test was performed with ATB-Fungus strip.A retrospective analysis was performed on the urine culture results from Jan 2008 to Dec 2012 by WHONET 5.6 software.Results A total of 273 strains were isolated,among which there were Candida albicans(37.4%),Candida glabrata(28.9%) and Candida tropicalis(27.8%);Most of the isolates came from ICU(58),urinary surgery(50) and internal medicine(49).Amphotericin B and 5-flucytosine had a strong antibacterial activity against Candida albicans,Candida tropicalis and Candida glabrata with the susceptibility rates not less than 98.6%;and the susceptibility rate to voriconazole was no less than 86.3%.Conclusion Candida albicans is predominant pathogen in urinary tract infection,followed by Candida glabrata and then Candida tropicalis.Amphotericin B and 5-fluorocytosine maintain strong antibacterial activities to Candida,and they are the first choice for treating Candida infections.Antifungal agents should be used scientifically and reasonably according the results of Candida culture and susceptibility test.