Bcl- 2,P~(53) ,C-erbB-2 protein expressions and their significance in lung cancer

? Objective To study Bcl 2,P 53 ,C erbB 2 protein expressions and their sigificance in the carcinogenesis,metastasis and prognosis of lung cancer.Methods Immunohistochemical LSAB technique was used to detect Bcl 2,P 53 and C erbB 2 protein expressions in 76 cases of lung cancer.Results The positive rate of bcl 2 protein in SCLC was much higher than that in adenocarcinoma(60.0%,16.0%,P0.05) and that in highly differentiated squamous cell carcinoma was much lower than that in poorly differentiated ones(30.8%,73.8%,P0.05).The positive rate of P 53 protein in highly differentiated adenocarcinoma was much lower than that in poorly differentiated one (30.0%,87.5%,P0.05),and in lymph node positive tissue was higher than that in lymph node negative tissues.The positive rate of cerbB 2 protein in adenocarcinoma was much higher than that in SCLS(52.2%,10.0%,P0.05),and that in highly differnetiated adenocarcinoma was much lower than that in poorly differentiated ones(22.2%,75.0%,P0.01).Bcl 2 and P 53 protein expression had correlation(P0.05).Conclusions Bcl 2 protein expression was correlated with tissue differentiation of lung cancer.With the increasing of differentiation grades,the expression of bcl 2 protein increased.P 53 gene alternation was correlated with carcinogenesis,positive lymph node status and progression of lung cancer.C erbB 2 gene alternation have little relation with SCLC,but closely relates to adenocarcinoma.Bcl 2 and P 53 expression has correlation. 〔