Expression of Bcl-2 protein in breast carcinoma

Aim: To probe the relationship between Bcl 2 protein expression and the prognosis of breast carcinoma. Methods:Expressions of Bcl 2 protein, P53 protein, ER, and PR in 69 cases of breast carcinoma and expression of Bcl 2 protein in 15 normal mammary gland tissues were determined by immunohistochemistry. Results: The positive rates of Bcl 2 protein, P53 protein, ER, and PR in breast carcinoma tissues were 65.2%, 47.5%,75.4%, and 69.6% respectively. The positive rate for Bcl 2 protein expressions in normal mammary gland tissues was 100%. Bcl 2 expression had close correlation with the size of carcinoma( P 0.01), estrogen, progestogen receptors ( P 0.01), and the grades in pathohistology ( P 0.01); it negatively correlated with P53 protein( P 0.05), positively correlated with hormone receptor, and did not correlated with subaxileary lymphnode metastasis( P 0.05). If Bcl 2 protein expression was positive, the 5 year survival rate was high. Conclusions:High Bcl 2 protein expression has close correlation with good prognosis and 5 year survival rate. Bcl 2 protein may have significant clinical value in the prognosis of breast carcinoma.