The Relationship Between Human Papillomavirus Types 16,18 E6 and p53 Expression in Cervical Carcinoma

Immunohistochemistry SP method was used to study the relation between HPV types 16,18 E6 and p53 protein expression in 68 cases of cervical carcinomas. The results show HPV\|16,18 E6 and p53 protein positive expression were detected in 60 and 17 of 68 cervical carcinomas, positive rates of HPV\|16,18 E6, p53 protein were 88.2% and 25.0% respectively; overexpression of HPV\|16,18 E6 protein were revealed in 59 cases of cervical carcinomas with p53 negative and poor positive expression in 54 cases, the both showed a negative corretation(P0.01). Expression of p53 was associated with histological types, its positive rate was 83.3% in adenocarcinoma and 17.2% in squamous cell carcinoma, there was a significant difference between adenocarcinoma and squamous cell carcinoma(P0.01).Positive expression of p53 was higher as clinical stage increased(P0.01).