Clinical observation of the regimen for docetaxel combined with cisplatin and dedaplain chemotherapy in the treatment of advanced non-small cell lung cancer

Objective:To detect the efficacy and the side effect of the regimen for docetaxel combined with cisplatin and Nedaplatin chemotherapy in the treatment with advanced non-small cell lung cancer.Methods: A total of 62 patients with advanced non small cell lung cancer were divided into the docetaxel combined with cisplatin group(group A,n=32) and the docetaxel combined with Nedaplatin group(group B n=30).Results:The efficacy of group A was 37.5%and group B was 38.7%,there was no significant difference between the two groups in curative effect(P0.05).A higher response rate of digestive reaction and nephrotoxicity(77.4%) occurred in group A,compared to that occurred in group B(60%),with a significant difference between the two groups(P0.01).There was no significant difference between two groups in the toxicity of kidney.There was a lower incidence of leucopenia response rate(50%) in group A than in group B(76.67%),with a significant difference between the groups(P0.05).There was a lower thrombocytopenia response rate(6.3%) in group A than in group B(26.67%),with a significant difference between the groups(P0.05).Conclusions:There is no significant difference between docetaxel combined with cisplatin group and nedaplain group and there is a lower digestive reaction and nephrotoxicity response rate in cisplatin group.And the main adverse reaction was myelosuppression and allergic reaction.