2003•PubMedRequires access

[The expression and activity of caspase-8 in the process of vitamin E succinate-induced apoptosis in human gastric carcinoma SGC-7901 cells].

Yao Li, Kun Wu, Weiping Yu

Abstract

OBJECTIVE: To investigate the role of caspase-8 in vitamin E succinate (VES)-induced apoptosis in human gastric carcinoma cells. METHODS: The expression and activity of caspase-8 were measured by the Western Blot method with fluorescence and DAPI staining. RESULTS: VES treatment induced the expression and activity of caspase-8 in a dose-dependent manner; the apoptosis ratio induced by VES was significantly decreased in SGC-7901 cells treated with caspase-8 inhibitor. CONCLUSION: Caspase-8 plays an important role in SGC-7901 cell apoptosis induced by VES.

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Key concepts: Apoptosis, DAPI, Western blot, Caspase 3, Vitamin C, Chemistry, Staining, Molecular biology