Antimicrobial activity analysis of fosfomycin against pathogens isolated from urine specimens

Objective To analyze the antimicrobial activity and characteristics of fosfomycin against commonly pathogens isolated from urine specimens and to provide laboratory evidence for clinical application of fosfomycin.Methods Standard agar dilution was used to study the antimicrobial activity of fosfomycin against 610 pathogens associated with urinary tract infection, including Escherichia coli 150 strains, Klebsiella pneumonia 150 strains, Enterobacter cloacae 100 strains, Acinetobacter baumannii 50 strains, Staphylococcus aureus 60 strains, Enterococcus faecalis 50 strains and Enterococcus faecium 50 strains. Results There were different susceptibility phenotypes and break points of minimum inhibitory concentration(MIC) to fosfomycin between different pathogens. Fosfomycin was highly active against Escherichia coli, the durg sensitive rate was 98%, the sensitive rate against Klebsiella pneumonia(90%) and Enterobacter cloacae(85%) was lower than that against Escherichia coli; Enterococcus faecium MIC value was slightly higher than Enterococcus faecalis; fosfomycin showed good activity against Staphylococcus aureus(90%), and the MIC values of methicillin-resistant isolated was higher than that of methicillin-susceptible strains; and the modal MICs for Acinetobacter baumannii were high concentration. Conclusion Fosfomycin has good antibacterial activity against common urinary system infection bacteria, but to consider the differences between different bacteria and drug resistance phenotype in clinical application.