2004•Huaxi yaoxue zazhiRequires access

Tanshinone II A prevents angiotensinII-induced hypertrophy of cardiomyocytes from rat

Li-ya Gong, Zhi Zheng, Xiong Wei, Sun Lianping

Abstract

OBJECTIVE To investigate the effect of TanshinoneⅡA(TSN) on the hypertrophy induced by angiotensinⅡ(AngⅡ)in the primary culture of neonatal rat cardiomyocytes.METHODS As an index of cardiomyocyte hypertrophy,protein synthesis rate was measured by 3H-Leucine incorporation.The proto-oncogene c-fos mRNA expression was assessed using reverse transcription polymerase chain reaction(RT-PCR).RESULTS Protein synthesis rate and proto-oncogene c-fos mRNA expression of cardiomyocytes increased significantly after AngⅡtreatment,and TSN inhibited these effects of AngⅡ.CONCLUSION TSN can prevent the hypertrophy of cardiomyocytes induced by AngⅡ,which may relate to the decreased expression of proto-oncogene c-fos mRNA by TSN.

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Key concepts: Chemistry, Messenger RNA, Muscle hypertrophy, Reverse transcription polymerase chain reaction, Angiotensin II, Reverse transcriptase, Oncogene, Renin–angiotensin system