Comparitive study of middle and mixed artificial livers in treatment of hepatic failure

Objective: Non-bioartificial liver was applied to clinic, but the reported efficacy was different. The aim of this article is to compare the efficacy and safety of middle (plasma exchange) and mixed (plasma exchange plus hemoperfusion absorption) in treatment of hepatic failure.Methods:Fifty-one patients with hepatic failure were treated with plasma exchange therapy (17 cases) and plasma exchange plus hemoperfusion adsorption therapy (34 cases). The data before and after treatment of liver function, renal function, blood routine test, prothrombin time (PT), prothrombin activity (PTa) were analyzed.Results:Clinical symptoms of patients were ameliorated after treatment. The levels of aminotransferase, total bilirubin, direct bilirubin, PT, the level of total serum proteins decreased significantly and PTa increased significantly after two therapies ( P 0.05 or P 0.01). There was no significant difference of descent or rising level between two groups ( P 0.1 or P 0.25).The side effects were poor and limited in all patients.Conclusion:Two therapies were effective in the treatment of hepatic failure.