The analysis of the outcome of stageIIInon-small cell lung cancer treated with chemoradiotherapy

Objective To retrospectively analyze the outcome of stageⅢnon-small cell lung cancer (NSCLC)treated with radiotherapy and chemoradiotherapy.Methods 56 patients who were treated with radio- therapy alone(RT group,28cases)or radiotherapy plus chemotherapy(CRT group,31cases)were entered into the database for analysis.All patients used the conventional fractionated radiotherapy,including conventional ra- diotherapy(29 cases)and three dimensional conformal radiation therapy(3DCRT,27 cases).The 31 patients treated with combined medality treatment all received cisplatin based chemotherapy.Results The overall re- sponse rate of CRT and RT group were 83.9% and 76.0%(P=0.75)respectively.The median survival time were 18 months and 10 months,respectively.The 1-,2-,3-year overall survival rate were 64.5%,41.3%, 37.2% for CBT group and 44.0%,26.7%,13.3% for RT group(P=0.0482).The 2-year local control rate were 31.3% and 9.3% ,respectively(P=0.12).There was no esophagitis and pneamonitis more than grade 3 in each group.And the differences of toxicity rates between the two groups were statistically insignificant.Con- clusion The combination of radiotherapy and chenmotherapy improved the overall survival of stageⅢnon-small cell lung cancer without increasing toxicity.