Percutaneous cool-tip radiofrequency ablation of advanced lung cancer

Objective To study efficacy and safety of percutaneous cool-tip radiofrequency ablation guided by computerized tomography(CT) in the treatment of advanced lung cancer.Methods Thirty-two patients with advanced lung cancers of 102 different pathological types were treated with MERP technique.The patients′blood pressure,pulse rate and blood oxygen saturation were monitored during the procedure.The hepatic,pulmonary and renal functions were examined before and after the procedure.The tumor bulk and its low-density shadow(LDS) were compared with CT before and after the treatment.Results There was no any change in the blood pressure,pulse rate and blood oxygen saturation before,immediately after termination and one month after the procedure,nor did the hepatic,pulmonary and renal function.The bulk of the tumor enlarged by the end of the first month after the therapy.The CT scanning of the tumor at the end of the third month revealed that of 102 tumors,23 showed CR(100% regression),53 PRa(80%-100% regression),24 PRb(50%-80% regression),and 2 NR(less than 50% regression).By the third month,the LDS of 102 tumors detected by CT showed 2 in type Ⅰ(less than 50%),43 in type Ⅱ(50%-80%) and 57 in type Ⅲ(more than 80%).Conclusion The cool-tip radiofrequency ablation is a promising mini-invasive technique for the treatment of advanced lung cancer with satisfactory efficacy and safety.