Correlation analysis of serum uric acid and carotid atherosclerosis in type 2 diabetes mellitus

AIM: To determine whether uric acid concentration is an independent factor associated with carotid atherosclerosis in type 2 diabetes mellitus (T2DM).METHODS: A cross-sectional study of 318 T2DM patients with or without carotid atherosclerosis was conducted.Uric acid and other T2DM risk factors,including age,T2DM duration,body-mass index (BMI),free blood glucose (FBG),systolic blood pressure (SBP),diastolic blood pressure (DBP),serum cholesterol (TC),triglyceride (TG),and blood white cells (WBCs),were analyzed.RESULTS: In Logistic regression analysis of carotid atherosclerosis,uric acid (P0.001) was higher in carotid atherosclerosis group.Uric acid,together with age(P=0.001) and SBP (P0.05),was associated with carotid atherosclerosis in T2DM.After adjustment of kidney function by uric acid /creatinine ratio,the difference disappeared.In multiple regression analysis of uric acid in all the groups,creatinine (P0.001),carotid atherosclerosis(P0.001),BMI(P=0.004) and WBCs(P=0.001) were independent determinants.CONCLUSION: Uric acid is an independent factor in T2DM with carotid atherosclerosis.The increased level may be associated with the injury of kidney function.