ScholarLens Back to search
2006•Shandong yiyaoRequires access

Expression and value of GM-CSF receptors on CD_(34) positive cells in bone marrow of patients with aplastic and myelodysplastic syndrome

Ying Li

Open publisher page 0 citations

Abstract

[Objective] To detect expression rate of granulocytemacrophage colony-stimulating factor receptors(GM-CSFR) on CD_(34) positive cells in bone marrow of patients with aplastic anemia(AA) and myelodysplastic syndrome(MDS).[Methods] The expression rates of GM-CSFR on CD_(34) positive cells in 14 AA patients, 23 MDS patients and 8 normal cases were detected by flow cytometry(FCM) and monoclonal antibody technique.[Results] The expression rate of GM-CSFR on CD_(34) positive cells in MDS group was higher than that in control group and AA group(P0.05).There was no significant difference between AA group and control group(P0.05).[Conclusion] It suggests that the quality of hematopoietic stem cells is normal in AA and the damaged quality of hematopoietic stem cells is one of the principal pathogenesis in MDS.

About this research paper

What this paper is about

[Objective] To detect expression rate of granulocytemacrophage colony-stimulating factor receptors(GM-CSFR) on CD_(34) positive cells in bone marrow of patients with aplastic anemia(AA) and myelodysplastic syndrome(MDS).[Methods] The expression rates of GM-CSFR on CD_(34) positive cells in 14 AA patients, 23 MDS patients and 8 normal cases were detected by flow cytometry(FCM) and monoclonal antibody technique.[Results] The expression rate of GM-CSFR on CD_(34) positive cells in MDS group was higher than that in control group and AA group(P0.05).There was no significant difference between AA group and control group(P0.05).[Conclusion] It suggests that the quality of hematopoietic stem cells is normal in AA and the damaged quality of hematopoietic stem cells is one of the principal pathogenesis in MDS.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

[Objective] To detect expression rate of granulocytemacrophage colony-stimulating factor receptors(GM-CSFR) on CD_(34) positive cells in bone marrow of patients with aplastic anemia(AA) and myelodysplastic syndrome(MDS).[Methods] The expression rates of GM-CSFR on CD_(34) positive cells in 14 AA patients, 23 MDS patients and 8 normal cases were detected by flow cytometry(FCM) and monoclonal antibody technique.[Results] The expression rate of GM-CSFR on CD_(34) positive cells in MDS group was higher than that in control group and AA group(P0.05).There was no significant difference between AA group and control group(P0.05).[Conclusion] It suggests that the quality of hematopoietic stem cells is normal in AA and the damaged quality of hematopoietic stem cells is one of the principal pathogenesis in MDS.

Key concepts: Aplastic anemia, Haematopoiesis, Bone marrow, Myelodysplastic syndromes, Flow cytometry, Stem cell, Pathogenesis, Monoclonal antibody

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression and value of GM-CSF receptors on CD_(34) positive cells in bone marrow of patients with aplastic and myelodysplastic syndrome — Research Paper | ScholarLens