2008•Chinese Journal of Drug Application and MonitoringRequires access

Inhibition effect of ampelopsin on proliferation of BEL-7404 human liver cancer cell

Yumeng Zhang

Abstract

Objective:To investigate the anti-tumor effect of ampelopsin in vitro.Methods:The growth inhibition was analyzed by MTT, cell colony and cell growth curve measurement in the liver carcinoma BEL-7404.Results:The ampelopsin could obviously inhibit the growth of cultured BEL-7404 cells, the IC50 in MTT assay is 22.99μg/mL; Ampelopsin could obviouly affect on the tumor cells'growth; The repressive ratio in cell colony assay is 100% when medicine density is over 9.88μg/mL, the repressive ratio in cell colony assay is 69.65% when medicine density is 6.58μg/mL.Conclusion:Ampelopsin can inhibit the growth of BEL-7404 in vitro.

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Key concepts: MTT assay, Cell growth, Medicine, IC50, In vitro, Cell, Growth inhibition, Cancer cell