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2009•Journal of University of South ChinaRequires access

Synthesis and Anticancer Activities of 7-Alkoxy Chrysin Derivatives

Zheng Xing

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Abstract

Objective To study the anticancer activity of 7-alkoxy chrysin derivatives. Methods 7-Alkoxy chrysin derivatives were prepared and their anticancer activities in vitro were evaluated by the standard MTT method. Results Compound 2b showed more stronger activity against HT-29 cells than 5-Fu,and compound 2a,2b,2e,2d had stronger activity against HL-60 cells than 5-Fu. Conclusion 7-Alkoxy chrysin derivatives possessed the potent anticancer activity.

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Objective To study the anticancer activity of 7-alkoxy chrysin derivatives. Methods 7-Alkoxy chrysin derivatives were prepared and their anticancer activities in vitro were evaluated by the standard MTT method. Results Compound 2b showed more stronger activity against HT-29 cells than 5-Fu,and compound 2a,2b,2e,2d had stronger activity against HL-60 cells than 5-Fu. Conclusion 7-Alkoxy chrysin derivatives possessed the potent anticancer activity.

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Available abstract

Objective To study the anticancer activity of 7-alkoxy chrysin derivatives. Methods 7-Alkoxy chrysin derivatives were prepared and their anticancer activities in vitro were evaluated by the standard MTT method. Results Compound 2b showed more stronger activity against HT-29 cells than 5-Fu,and compound 2a,2b,2e,2d had stronger activity against HL-60 cells than 5-Fu. Conclusion 7-Alkoxy chrysin derivatives possessed the potent anticancer activity.

Key concepts: Chrysin, Alkoxy group, Chemistry, In vitro, MTT assay, Pharmacology, Stereochemistry, Biochemistry

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