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Synthesis and Biological Evaulation of Chrysin Derivatives

Xukun Deng

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Abstract

Chrysin derivate was synthesized to evaluate its biological activities.5,7-dihydroxyflavone as raw material and with the chemical methods of substitution reaction,hydrolysis and amide condensation reaction,the chrysin was synthesized,and then its antiproliferative activities against human cancer cell EC109,HepG2,SW480,and Hela were evaluated.The anti-caner activities against HepG2,SW480 of chrysin derivate manifestly increased,compared with chrysin.Compound 3 displayed better of anti-cancer activities than chrysin against HepG2,SW480.

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What this paper is about

Chrysin derivate was synthesized to evaluate its biological activities.5,7-dihydroxyflavone as raw material and with the chemical methods of substitution reaction,hydrolysis and amide condensation reaction,the chrysin was synthesized,and then its antiproliferative activities against human cancer cell EC109,HepG2,SW480,and Hela were evaluated.The anti-caner activities against HepG2,SW480 of chrysin derivate manifestly increased,compared with chrysin.Compound 3 displayed better of anti-cancer activities than chrysin against HepG2,SW480.

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Available abstract

Chrysin derivate was synthesized to evaluate its biological activities.5,7-dihydroxyflavone as raw material and with the chemical methods of substitution reaction,hydrolysis and amide condensation reaction,the chrysin was synthesized,and then its antiproliferative activities against human cancer cell EC109,HepG2,SW480,and Hela were evaluated.The anti-caner activities against HepG2,SW480 of chrysin derivate manifestly increased,compared with chrysin.Compound 3 displayed better of anti-cancer activities than chrysin against HepG2,SW480.

Key concepts: Chrysin, HeLa, Chemistry, Amide, Hydrolysis, Combinatorial chemistry, Stereochemistry, Organic chemistry

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