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2011•Sichuan Medical JournalRequires access

Influence of liver X receptor-α activator T0901317 on expression of MPO and TNF-α in rat lung with acute lung injury

Jing Xu

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Abstract

Objective To investigate inhibitory action of T0901317,a liver X receptor-α activator,on expression of MPO and TNF-α in rats with acute lung injury(ALI).Methods 72 male Wistar rats were randomly divided into three group: control group(C group),LPS group(L group),T0901317 group(LT group).The rats were killed at 1h,2h,4h,8h after treatment.The lung tissue was collected,myeloperoxidase activity,lung histopathologic changes and expression of TNF-α were observed.Results In rats with ALI,myeloperoxidase activity rised compared with control group(P0.05),and lung injury is more severe than that in rats of control group.TNF-α increased markedly in lung homogenate and blood serum at the same period(P0.05).However,The expression of TNF-α and myeloperoxidase activity in rat lung tissues in LT group were significantly declined.Conclusion T0901317 has played an anti-inflammatory effect through suppressing the expression of TNF-α and myeloperoxidase activity in rat lung with acute lung injury.

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Objective To investigate inhibitory action of T0901317,a liver X receptor-α activator,on expression of MPO and TNF-α in rats with acute lung injury(ALI).Methods 72 male Wistar rats were randomly divided into three group: control group(C group),LPS group(L group),T0901317 group(LT group).The rats were killed at 1h,2h,4h,8h after treatment.The lung tissue was collected,myeloperoxidase activity,lung histopathologic changes and expression of TNF-α were observed.Results In rats with ALI,myeloperoxidase activity rised compared with control group(P0.05),and lung injury is more severe than that in rats of control group.TNF-α increased markedly in lung homogenate and blood serum at the same period(P0.05).However,The expression of TNF-α and myeloperoxidase activity in rat lung tissues in LT group were significantly declined.Conclusion T0901317 has played an anti-inflammatory effect through suppressing the expression of TNF-α and myeloperoxidase activity in rat lung with acute lung injury.

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Available abstract

Objective To investigate inhibitory action of T0901317,a liver X receptor-α activator,on expression of MPO and TNF-α in rats with acute lung injury(ALI).Methods 72 male Wistar rats were randomly divided into three group: control group(C group),LPS group(L group),T0901317 group(LT group).The rats were killed at 1h,2h,4h,8h after treatment.The lung tissue was collected,myeloperoxidase activity,lung histopathologic changes and expression of TNF-α were observed.Results In rats with ALI,myeloperoxidase activity rised compared with control group(P0.05),and lung injury is more severe than that in rats of control group.TNF-α increased markedly in lung homogenate and blood serum at the same period(P0.05).However,The expression of TNF-α and myeloperoxidase activity in rat lung tissues in LT group were significantly declined.Conclusion T0901317 has played an anti-inflammatory effect through suppressing the expression of TNF-α and myeloperoxidase activity in rat lung with acute lung injury.

Key concepts: Myeloperoxidase, Medicine, Lung, Activator (genetics), Internal medicine, Tumor necrosis factor alpha, Endocrinology, Receptor

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Influence of liver X receptor-α activator T0901317 on expression of MPO and TNF-α in rat lung with acute lung injury — Research Paper | ScholarLens