Acute toxicity experiment of Sprague-Dawley rats exposed i.p. to cadmium chloride.

Aim To observe the acute toxicity of rats exposed i.p.to cadmium chloride (CdCl2),and determine the median lethal dose (LD50).Methods The dose range leading to the death rate 100% and 0% of Sprague-Dawley rats after exposed i.p.to CdCl2,and the rats were randomly divided into 6 experimental groups and 1 control group each consisted of 8 rats.Results The absolute lethal dose was 26.00 mg/kg and maximal tolerance dose was 11.54 mg/kg.The doses in each experimental groups was 26.00,22.10,18.79,15.97,13.57 and 11.54 mg/kg in tune.The rats usually died of Cd intoxication within 8 hours and a few of rats died in 72 hours.The LD50 of rats exposed i.p.to CdCl2 was 18.37 mg/kg,with a 95% confidence interval of 16.56～20.38 mg/kg.Conclusions The CdCl2 is a kind of high toxic chemicals according to the harmful classification of occupational exposed poison in China,This experiment has offered scientific data for acute toxicity test of cadmium compounds.