Comparison of the Different Basal Volume of Sufentanil for Postoperative Patient-Controlled Intravenous Analgesia(PCIA)

Objective To observe the analgesic effect and the side-effect of sufentanil with different basal volumes used for PCIA. Methods Sixty ASA I～II patients(32 male,28 female) aged 20-70 year weighing 45-98 kg undergoing elective thoracal or abdominal surgery under general anesthesia were separated into three groups randomly receiving PCIA with sufentanil 0.001 μg·kg~(-1)·min~(-1)(S1,n=20),0.000 5 μg·kg~(-1)·min~(-1)(S2,n=20),0 μg·kg~(-1)·min~(-1)(S3,n=20).PCA 1 mL(sufentanil 2 μg·mL~(-1)) was used in three groups with a 5 min lock-time through patient-controlled analgesia device.Visual analogue scale(VAS) scores in quiet and cough,cumulative volumes of the intravenous drugs,vital signs including SPO2,HR,RR,and side-effect including sedation scores,nausea,vomit,pruritus and other analgesics were assessed after 6,24 and 48 h of postoperative analgesia. Results VAS scores decreased when the basal volumes of sufentanil increased.VAS scores of group S1 were similar to group S2(P0.05),lower than group S3(P0.05) in quiet,were lower than group S2(P0.05) and group S3(P0.01) on movement.The rate of nausea in group S1 were lower than S2.Vital signs including SPO_(2) 、HR 、RR were in the normal range. Conclusion Sufentanil 0.001 μg·kg~(-1)·min~(1) can provide satisfying analgesia without increasing the side-effect.