Role of intercellular adhesion molecule-1 in the lung inury induced by mechanical ventilation

Objective To investigate the possible role of intercellular adhesion molecule-1 (ICAM-1) in the lung injury induced by mechanical ventilationMethods Twenty-four normal healthy small pigs, ventilated with continuous different tidal volume, were randomly divided into control group, low tidal volume group (group A), middle tidal volume group (group B) and high tidal volume group (group C)The expression of ICAM-1 protein on pulmonary vascular endothelium cells, tumor necrosis factror-α (TNF-α) levels and myloperoxidase (MPO) activities in serum and lung were observed with immunohistochemisty, enzyme linked immunosorbent assay and MPO measurement 1d,3d and 7d following ventilation respectivelyResults The levels of TNF-α and MPO in serum and lung and the number of ICAM-1 protein expression were higher in group A, B and C than those in control group (P005 or 001), in addition, TNF-α value was at its maximum 3d later, MPO value and the number of ICAM-1 protein expression were at their maximum 7d later, with the most changes in group A and group C Conclusions ICAM-1 may play an importment role in the lung injury induced by mechanical ventilation, which is possiblely mediated by TNF-α