ScholarLens Back to search
2010•China CancerRequires access

Effect of Neoadjuvant Chemotherapy on Expression of ER, HER-2 in Breast Cancer and Their Significance

Dahua Mao

Open publisher page 0 citations

Abstract

[Purpose] To investigate the expression of ER and HER-2 in breast cancer tissue and its clinical significance. [Methods] Expressions of ER, HER-2 in 100 cases patients with breast cancer were detected by immunohistochemistry before and after neoadjuvant chemotherapy. The relationship of ER and HER-2 with response of neoadjuvant chemotherapy was analyzed. [Results] The overall response rate of neoadjuvant chemotherapy was 79%. Response rate in patients with negative expression of ER was higher than that with positive expression of ER(P0.05). There was no significant relation between the response and HER-2 expression(P0.05). Expression of ER and HER-2 did not change significantly after neoadjuvant chemotherapy (P0.05). [Conclusion] Neoadjuvant chemotherapy did not significantly influence on status of ER and HER-2. ER may be used to predict the therapeutic response of neoadjuvant chemotherapy in breast cancer.

About this research paper

What this paper is about

[Purpose] To investigate the expression of ER and HER-2 in breast cancer tissue and its clinical significance. [Methods] Expressions of ER, HER-2 in 100 cases patients with breast cancer were detected by immunohistochemistry before and after neoadjuvant chemotherapy. The relationship of ER and HER-2 with response of neoadjuvant chemotherapy was analyzed. [Results] The overall response rate of neoadjuvant chemotherapy was 79%. Response rate in patients with negative expression of ER was higher than that with positive expression of ER(P0.05). There was no significant relation between the response and HER-2 expression(P0.05). Expression of ER and HER-2 did not change significantly after neoadjuvant chemotherapy (P0.05). [Conclusion] Neoadjuvant chemotherapy did not significantly influence on status of ER and HER-2. ER may be used to predict the therapeutic response of neoadjuvant chemotherapy in breast cancer.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

[Purpose] To investigate the expression of ER and HER-2 in breast cancer tissue and its clinical significance. [Methods] Expressions of ER, HER-2 in 100 cases patients with breast cancer were detected by immunohistochemistry before and after neoadjuvant chemotherapy. The relationship of ER and HER-2 with response of neoadjuvant chemotherapy was analyzed. [Results] The overall response rate of neoadjuvant chemotherapy was 79%. Response rate in patients with negative expression of ER was higher than that with positive expression of ER(P0.05). There was no significant relation between the response and HER-2 expression(P0.05). Expression of ER and HER-2 did not change significantly after neoadjuvant chemotherapy (P0.05). [Conclusion] Neoadjuvant chemotherapy did not significantly influence on status of ER and HER-2. ER may be used to predict the therapeutic response of neoadjuvant chemotherapy in breast cancer.

Key concepts: Medicine, Breast cancer, Chemotherapy, Oncology, Immunohistochemistry, Internal medicine, Clinical significance, Neoadjuvant therapy

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effect of Neoadjuvant Chemotherapy on Expression of ER, HER-2 in Breast Cancer and Their Significance — Research Paper | ScholarLens