2010•China Animal Husbandry & Veterinary MedicineRequires access

Molecular Structure and Function of Interferon Regulatory Factor-1

Deng Xue-mei

Abstract

Interferon regulatory factor 1(IRF-1)is a important multifunctional transcription factor for regulating of expression of interferon(IFN)and having cantivirus action,antineoplastic activity.Indeed,IRF-1selectively modulates different sets of genes,depending on the cell type in order to evoke appropriate responses in each.The author summarizes the structure,the transcriptional regulation and the multiple biological effects.

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Key concepts: Interferon regulatory factors, IRF1, Transcription factor, IRF8, Interferon, Biology, Function (biology), Computational biology