Progress of interferon regulatory factor 5

Interferon regulatory factor 5(IRF-5) can induce the expressions of IFN-α, IFN-β and promote the secretion of cytokines, including IL-6, IL-12 b, IL-17, IL-23, TNF etc.IRF-5 is involved in the process of immune response, cell growth, cell differentiation, cell apoptosis, tumorigenesis and cell signal transduction.For that reason, IRF-5 plays an important role in the occurrence and progress of many diseases in humans.Further studies of IRF-5 will better elucidate the pathogenesis of related diseases and provide theoretical basis for treatment of these diseases and the corresponding therapeutic targets. Key words: Interferon regulatory factor 5; Interferon; Systemic lupus erythematosus; Tumor