Influential factors of urine albumin in newly diagnosed type 2 diabetic patients with microalbuminuria

Objective To explore the influential factors of urinary albumin excretion in newly diagnosed type 2 diabetic patients with microalbuminuria.Methods Sixty initially diagnosed type 2 diabetic patients were included in the present study,and divided into simple diabetic group(DM)and diabetic group with microalbuminuria(DM+UAER)according to urinary albumin excretion rate(UAER).The body mass index(BMI),waist hip radio(WHR),fasting plasma glucose(FPG),2-hour plasma glucose(2hPG),glycated haemoglobin(HbA1c),triglycerides(TG),total cholesterol(TC),high density lipoprotein(HLD),low density lipoprotein(LDL),fasting serum insulin(FINS),fasting C peptide(FCPS),and homeostasis model assessment-insulin resistance index(HOMA-IR)in 2 groups were recorded and the relationship with UAER were observed.Results Compared with DM group patients,the WHR,FPG,2hPG and HOMA-IR were significantly higher in DM+UAER group(P0.05).Pearson correlation analysis revealed UAER was positively correlated with FPG(r=0.521),2hPG(r=0.397),HOME-IR(r=0.26)(P0.05).Stepwise multiple regression analysis revealed that FPG(r=0.521,P0.01)was independently influential factor of UAER.Conclusion The level of plasma glucose and the degree of insulin resistant in initially diagnosed type 2 diabetic patients with microalbuminuria are higher than those simple diabetic patients.Fasting plasma glucose is the independently influential factor of urinary albumin excretion.