2005•Journal of clinical otorhinolaryngologyRequires access
Expression of hypoxia-inducible factor-1α in middle ear cholesteatoma
Yang Liu
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Abstract
Objective:To explore the pathogenetic mechanism of middle ear cholesteatoma,the aim of this study is to detect the expression of Hypoxia-inducible factor-1α in middle ear cholesteatoma and normal external ear canal skin.Method:We used the technology of immunohistochemistry to examine the expression of Hypoxia-inducible factor-1α in thirty-one middle ear cholesteatomas and ten samples of normal external ear canal skin.Result:The expression of HIF-1α was extremely higher in middle ear cholesteatomas than in normal external ear canal skin(P 0.05).Conclusion:We found that the higher expression of Hypoxia-inducible factor-1α in middle ear cholesteatomas,so we think that Hypoxia-inducible factor-1α play an important role in the pathogenetic process of middle ear cholesteatoma, and hypoxia may be an incentive in the pathogenetic mechanism of middle ear cholesteatoma.