Preparation and characterization of solid lipid nanoparticles loaded octyl methoxycinnamate

Preparation and properties of solid lipid nanoparticles carried octyl methoxycinnamate(OMC)were studied.The influence of octyl methoxycinnamate(OMC)and pH value on the distribution,size,Zeta potential of solid lipid nanoparticle were studied.Meanwhile the configuration,particle size,composition and sunscreen properties were characterized.The result showed that the Zeta potential of solid lipid nanoparticle was about 40 mV with optimizing composition and middle or weak basic pH condition.The average particle size of solid lipid nanoparticle was about 150 nm and the particle distribution was homogeneous.Particle configuration was spherical with or without OMC and little flocculation.Carried OMC increased the particle size.OMC with lipid material,emulsifier formed the solid lipid nanoparticle together but not carried in the core.The solid lipid nanoparticle with OMC have good ultraviolet adsorption and the synergy function was between the solid lipid nanoparticles and sunscreen.