The clinical significance of early combinational detection of HbAlc, Cys-C and β_2-MG in patients with diabetic nephropathy

Objective To evaluate the diagnosis value of HbA1c, Cys-C, β2-MG of early diagnosis in patients with diabetic nephropathy. Methods A total of 94 patients were divided into without albuminuria group, microalbuminuria group and clinical albuminuria group, selected health physical examination patient of 40 cases as control group,HbA1c、β2-MG、Cys-C were measured and compared with control group. Results HbA1c, Cys-C and β2-MG of patients with diabetic nephropathy group were significantly increased(P 0.05), microalbuminuria group and clinical albuminuria group had highly statistically significant(P 0.01)compared with control group, levels of HbA1c, Cys-C and β2-MG were positively correlated(r = 0.2763,0.4518,P 0.05), HbA1c, Cys-C and β2-MG of control group's comprehensive positive detection rate was 5.0%, and the microalbuminuria group and clinical albuminuria group were 88.6% and 93.1% respec-tively, albuminuria group joint test positive rate were significantly higher than that of control group(χ2=9.26,P 0.05),indicated that the three joint detection could improve detectable rate of early type 2 diabetes. Conclusion The HbA1c、Cys-C、β2-MG sensitive to early diagnosis and treatment of diabetes renal injury, test positive for joint detection rate is higher than the individual, it has important clinical value in the prevention and delay of diabetic nephropathy.