In vivo bioluminescence imaging technology and its applications in the field of gastrointestinal research

In vivo bioluminescence imaging technology is a kind of nonradioactive,noninvasive,super-sensitivity and real-time dynamics detection technology in molecular biology.The recent development of in vivo bioluminescence imaging technology has provided real-time,in situ,dynamic and noninvasive observation to biological response in vivo.Compared with other traditional imaging technique such as computed tomography(CT),magnetic resonance imaging(MRI),positron emission tomography(PET) and single photon emission computed tomography(SPECT),bioluminescence imaging is showed great superiority in life science research field.At present,In vivo bioluminescence imaging technology has become a powerful tool to detect molecular and cellular events in small animals,and more and more widely used in the foundation of life science research field.In recent years,because of its high degree of specificity and sensitivity,bioluminescence imaging technology is gradually applied in the field of oncology and it shows a good application prospects.This paper presents an overall review of the imaging characteristics,technique principles,and application in the research field of gastrointestinal of in vivo bioluminescence imaging technology.